16980-89-5 Usage
Uses
Used in Pharmaceutical Industry:
Bucladesine sodium is used as a cardiac stimulant for the treatment of cardiac insufficiency, especially after heart surgery. It is also used as a vasodilator due to its peripheral vasodilatory properties.
Used in Stem Cell Research:
Bucladesine sodium is used as a medium supplement for neural crest stem cells (NCSCs) differentiation, aiding in the development and understanding of stem cell therapies.
Used in Cryopreservation:
It is used as a component of the thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons, which is crucial for the preservation and revival of these cells for further research and potential therapeutic applications.
Used in Neuroscience Research:
Bucladesine sodium is used in serum-free Dulbecco's modified eagle's medium (DMEM) to induce astrocyte differentiation, contributing to the study of astrocyte function and development in the central nervous system.
Originator
Daiichi Seiyaku; Seishin Seiyaku (Japan)
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
References
1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?13212) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?5113) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?2334) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?61395) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270
Check Digit Verification of cas no
The CAS Registry Mumber 16980-89-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,9,8 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16980-89:
(7*1)+(6*6)+(5*9)+(4*8)+(3*0)+(2*8)+(1*9)=145
145 % 10 = 5
So 16980-89-5 is a valid CAS Registry Number.
