18368-61-1Relevant articles and documents
Substitution of the nitro group with Grignard reagents: Facile arylation and alkenylation of pyridine N-oxides
Zhang, Fang,Zhang, Song,Duan, Xin-Fang
supporting information, p. 5618 - 5620 (2013/01/15)
The unprecedented substitution of a nitro group with aryl or alkenyl groups of Grignard reagents affords 2-aryl or alkenylpyridine N-oxides in modest to high yields with high chemoselectivity. This protocol allows a simple and clean synthesis of various 2
Zirconium-catalysed Oxidation of Primary Aromatic Amines to Nitro Compounds Using tert-Butylhydroperoxide
Krohn, Karsten,Kuepke, Jochen,Rieger, Hagen
, p. 335 - 339 (2007/10/03)
A broad range of primary aromatic amines (1a-x) with electron donating and accepting substituents are oxidized in good to excellent yields to the nitro compounds 3a-x using tert-butylhydroperoxide as the oxidant and Zr(OtBu)4 as the catalyst. The corresponding nitroso compounds 2m,-2n, 2s and 2u can be isolated in the conversion of electron-rich anilines 1m, 1n, 1s and 1u. The aminopyridines 5a-d are also converted to the corresponding nitropyridines 6a-d, but in lower yields (41-47%).
