4418-61-5Relevant articles and documents
Rapidly, highly yielded and green synthesis of dihydrotetrazolo[1,5-a]pyrimidine derivatives in aqueous media using recoverable Pd (II) thiazole catalyst accelerated by ultrasonic: Computational studies
Abu-Dief, Ahmed M.,Alsoliemy, Amerah,El-Dabea, Tarek,El-Metwaly, Nashwa M.,El-Remaily, Mahmoud Abd El Aleem Ali Ali,Khalifa, Mohamed E.,Soliman, Ahmed M. M.
, (2021/07/02)
Here, we synthesized new thiazole complexes from Cu (II), Fe (III), and Pd (II) ions. Such complexes were characterized to present their chemical formulae, firstly. The octahedral geometry was suggested for the investigated complexes except Pd (II) complex (ARPTPd), which has a square-planer arrangement. ARPTPd was planned to be used as a catalyst for synthesis of dihydrotetrazolo[1,5-a]pyrimidine derivatives at mild conditions. The catalytic activity of ARPTPd complex in four-components reaction approach was deliberately monitored till it reaches the most favorable conditions. The advantages of suggested catalyst were basically summarized by using green solvent (H2O), lower reaction time, and high products yields. Also, the superiority of ARPTPd complex and ultrasonic irradiation towards synthesis of dihydrotetrazolo[1,5-a]pyrimidine derivatives was revealed compared with other Lewis acids, basic, and ionic liquid catalysts. Furthermore, the mildness of conversion and compatibility with different functional groups makes it attractive. In addition, in consecration, computational aspects were often taken according to their effect on the declaration or discrimination of variable functional characteristics. Crystal packing systems of complexes were configured to extract important surface properties. DFT study was also applied to explain the causes behind the superiorly of ARPTPd complex. Also, the optimization process for intermediates was executed to support the suggested mechanism. Finally, this simple, economical, and green catalytic procedure may be applied to the industry in future.
Preparation method of 1-tetrazole acetate
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Paragraph 0027; 0030, (2020/07/21)
The invention relates to the field of organic synthesis, and discloses a preparation method of 1-tetrazole acetate, which comprises the following steps: 1) taking aminoguanidine carbonate as a raw material, regulating to acidity with an acid solution, cooling, dropwisely adding a sodium nitrite water solution, regulating the pH value to alkalinity, and carrying out reflux cyclization to generate 5-aminotetrazole; 2) reacting 5-aminotetrazole with chloroacetic acid under an alkaline condition to synthesize 1-acetic acid-5-aminotetrazole, and 3) finally reducing with a reducing agent to remove amino to obtain 1-tetrazole acetate. Compared with the prior art, the method provided by the invention is safer and more environment-friendly, and the obtained product has high yield and purity.
Production process of 5-aminotetrazole
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Paragraph 0017-0024, (2021/01/15)
The invention belongs to the technical field of chemical synthesis, and particularly discloses a production process of 5-aminotetrazole, which adopts the following synthesis route: aminoguanidine bicarbonate and sulfuric acid are adopted to generate aminoguanidine sulfate; diazotization reaction is carried out on aminoguanidine sulfate and sodium nitrite to generate amidine azide sulfate; and cyclization reaction is performed on the amidine azide sulfate under the action of ammonia water to generate the 5-amino tetrazole. The path is good in safety and few in byproducts; the invention also provides a specific process flow, the process is simple, the operation is easy, and the product yield is high; according to the invention, a high-purity 5-amino tetrazole finished product is obtained bystep-by-step conversion in the diazotization process, control of the addition mode of sodium nitrite and strict control of the temperature and pH in the diazotization and cyclization reaction processes.
Facile synthesis of tetrazolo[1,5-a]pyrimidine with the aid of an effective gallic acid nanomagnetic catalyst
Maleki, Ali,Niksefat, Maryam,Rahimi, Jamal,Azadegan, Sepide
, p. 103 - 110 (2019/05/06)
The present work is the first report of nano-Fe3O4@SiO2-NH-gallic acid in multicomponent reactions as a catalyst. One-pot condensation of various aromatic aldehydes, ?-ketoesters and 5-aminotetrazole to deliver the desired tetrazolo[1,5-a]pyrimidine derivatives is investigated. It involves successful surface modification of Fe3O4@SiO2-NH2 as a potent magnetic support with a well-known natural acid which attracts considerable interests because of its applications in different sciences. This reusable magnetically separable nanocatalyst provides a convenient and reliable method for high yield tetrazole derivatives synthesis in short reaction times with wide variety range of the products and facile isolation. Acid grafting on the surface of amine-functionalized silica-coated magnetic nanoparticles confirmed by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA) and energy-dispersive X-ray (EDX) analysis techniques. Structural characterization included scanning electron microscopy (SEM) images along with transmission electron microscopy (TEM) images and vibrating sample magnetometer (VSM) curve applied for morphology and magnetism type determination of the resulted nanocatalyst, respectively.
Synthesis of 5 - amino tetrazole method
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Paragraph 0028; 0029; 0030, (2019/06/13)
Synthesis of 5 - amino tetrazole method, in order to hydrazine hydrate, lime nitrogen, sodium nitrite, inorganic acid and inorganic base as the obtained 5 - amino tetrazole. The method through the metathesis reaction, addition reaction and diazo isomerization reaction of the cyano lead lime nitrogen into the aminoguanidine, then generating aminoguandine isomerization reaction to synthesize 5 - amino tetrazole. The invention compared with the traditional method, has the following advantages: (1) price cheap raw materials as the starting raw material, synthetic product is obtained; (2) simplified 5 - amino tetrazole operation process, reduce the reaction solvent types and process the complexity of the operation, reduces the cost of material and production cost, reduces the 5 - amino tetrazole synthesis cost of, improve the market competitiveness of the product. It has high efficiency, high yield, low cost, easy operation and the like.
A 5 - substituted four nitrogen azole compound of synthetic method (by machine translation)
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Paragraph 0016; 0017; 0019, (2019/04/04)
The invention discloses a 5 - substituted four nitrogen azole compound of synthetic method, the synthesis method of the process is as follows: to point pen in the autoclave (I) indicated by the nitrile compounds, sodium azide, nickel ferrite and carboxylic acid ammonium ion exchange resin, added with an organic solvent to the cyclization reaction, the reaction solution after the reaction is finished filter, pickling, desolvation and heavy after crystallization, as shown in formula (II) of the 5 - substituted tetrazole compounds, yield is 85 - 95%, purity ≥ 99%; Formula (I) in the formula (II), the substituent R1 Is phenyl, substituted phenyl, C1 - C3 alkyl or amino; substituted phenyl substituent is methyl, methoxy, F or nitro. The invention of 5 - substituted tetrazole compounds synthesis method, adopt the catalytic ferrous acid nickel and carboxylic acid ammonium ion exchange resin catalyst combination, the carboxylic acid [...], not only good general the reaction substrate, the reaction yield is high, and the catalyst is easily separated and recycled, the production cost is reduced and the three waste emissions. (by machine translation)
Cobalt-promoted regioselective preparation of aryl tetrazole amines
Lakshmi, Kondraganti,Babu, Manabolu Surendra,Ramachandran, Dittakavi
, (2018/04/24)
Abstract: A highly general, efficient and simple methodology for the regioselective synthesis of aryl tetrazole amines has been explored. The present method involves consecutive desulphurization and C- N cross-coupling reaction. Cheap, readily available and air stable cobalt catalyst has been used for this methodology. In addition, the substrate scope has been demonstrated. Graphical Abstract: A highly general, efficient and simple methodology for the regioselective synthesis of aryl tetrazole amines has been explored. The present method involves consecutive desulphurization and C- N cross-coupling reaction.
Temperature dependent regioselective synthesis of aryl tetrazole amines using copper source
Murthy Boddapati,Emmanuel Kola,Kesana, Surendra Babu,Bollikolla, Hari Babu
, p. 177 - 183 (2018/05/09)
One pot highly efficient and simple protocol for the construction of aryl tetrazole amines via desulphurization/substitution/electro cyclization/C-N cross coupling reactions from thiourea with the use of cheap, readily available and air stable copper sour
Production process of 5-amino tetrazole
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Paragraph 0001, (2017/07/19)
The invention relates to a production process of 5-amino tetrazole. 5-amino tetrazole is an important chemical product. The technological process is briefed as the following: adding a certain amount of dicyanodiamide, sodium azide and excess 36.5% hydrochloric acid into a reaction kettle, carrying out condensation reaction under an aqueous phase condition fully to generate 5-amino tetrazole; then performing crystallization separation; using a 30% sodium hydroxide solution to absorb gaseous hydrazoic acid overflowing during crystallization to generate sodium azide for reuse; further conducting centrifugation on the liquid material to separate crystals and a mother solution, and outputting the mother solution as wastewater; dissolving the crystals in water, then conducting further refining to dissolve salt contained in a crude product in water, thus making preparations for the next step separation; carrying out centrifugal separation after dissolving salt in water, separating the product crystals insoluble in water from supernate, outputting the separated supernate as wastewater, drying the product crystals, and generating waste gas during drying.
A novel magnetically recyclable silver-loaded cellulose-based bionanocomposite catalyst for green synthesis of tetrazolo[1,5-a]pyrimidines
Maleki, Ali,Ravaghi, Parisa,Aghaei, Morteza,Movahed, Hamed
, p. 5485 - 5494 (2017/09/23)
5-Methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylic ester derivatives were efficiently synthesized by reaction of methyl or ethyl acetoacetate, 5-aminotetrazole (produced from 2-cyanoguanidine and sodium azide), and various aromatic aldehydes in presence of a new cellulose-based Ag-loaded magnetic bionanostructure. This protocol offers many advantages such as short reaction time, high yield, the remarkable magnetic property of the nanocomposite, and easy separation of the nanocatalyst from the reaction mixture without considerable loss of catalytic activity. Furthermore, X-ray diffraction analysis, field-emission scanning electron microscopy, and energy-dispersive X-ray (EDX) analysis were used to characterize the prepared nanocatalyst.
