71254-71-2Relevant articles and documents
Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase
Banoglu, Erden,Jordan, Paul M.,Kretzer, Christian,Werz, Oliver,?al??kan, Burcu,Ergül, Azize Gizem,Maz, Tu??e Gür,Ol?a?, Abdurrahman
, (2022/02/14)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is recognized as a promising therapeutic target for next-generation anti-inflammatory drugs to treat inflammatory diseases. In this study, we report the identification of new, potent and selectiv
In vitro, in vivo and in silico-driven identification of novel benzimidazole derivatives as anticancer and anti-inflammatory agents
Chandrashekarappa, Revanasiddappa B.,Merugumolu, Vijay K.,Poojary, Boja,Rangappa, Shobith,Sathyanarayana, Reshma,Srinivasa, Sudhanva M.
, (2021/08/24)
The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via “one-pot” nitro reductive cyclization (6a–o). In each case, compounds were determined by the elemental analyses, FT-IR, mass, 1H and 13
HMOX1 inducers
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Page/Page column 20-21; 51, (2020/09/18)
The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, anticancer, antimicrobial and in silico studies
Kumar, Naveen,Sreenivasa, Swamy,Kalal, Bhuvanesh Sukhlal,Kumar, Vasantha,Holla, Bantwal Shivarama,Pai, Vinitha Ramanath,Mohan, Nadigar Revansiddappa,Govindaiah, Shivaraj
, p. 994 - 1005 (2019/10/28)
Background: Cancer is a fatal disease for mankind; continuous research is still going on for the invention of potent anticancer drugs. In this view, 1, 3, 4-Oxadiazoles are privileged molecules which attracted medicinal chemists towards their anticancer p
Microwave-assisted synthesis of benzimidazole derivatives through nitro reductive cyclization and their biological study
Manju,Kalluraya, Balakrishna,Asma,Kumar, Madan S
, p. 415 - 422 (2018/09/25)
A simple, effective, and eco-friendly synthesis of new benzimidazole-bearing aromatic/heteroaromatic compounds (4 a-o) using sodium dithionite as an effective reductive cyclizing reagent in dimethyl sulfoxide under microwave method is described. The newly
Novel benzimidazole-oxadiazole hybrid molecules as promising antimicrobial agents
Shruthi,Poojary, Boja,Kumar, Vasantha,Hussain, Mumtaz Mohammed,Rai, Vaishali M.,Pai, Vinitha R.,Bhat, Mahima,Revannasiddappa
, p. 8303 - 8316 (2016/02/09)
In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-[1,2,4]-oxadiazol-5-yl)-1-methyl-1H-benzo[d]imidazole hybrid molecules as promising antimicrobial agents. The core moiety 2-aryl-ethyl-1H-benzo[d]imidazole-5-
HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR
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Paragraph 0230; 0231; 0232; 0233, (2013/04/10)
A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.
